主体-病原体的共同进化促进了一般性,广泛的耐药性的进化,并减少了外来病原体溢出风险
Samuel V Hulse1, Janis Antonovics2, Michael E Hood3
1University of Maryland at College Park, Maryland, USA.
bioRxiv : the preprint server for biology
|August 14, 2023
概括
宿主-病原体的共同进化可以增加一般的疾病抵抗力,降低外来病原体入侵风险. 这一过程增强了宿主遗传多样性和对本土和外来病原体的抵抗力.
科学领域:
- 进化生物学 进化生物学
- 植物病理学 植物病理学
- 人口遗传学 人口遗传学
背景情况:
- 宿主耐药性的遗传变异会影响病原体的传播.
- 一般耐药性影响外来病原体的传播,而特异性耐药性则准特有病原体.
- 敌对的共同进化塑造了宿主-病原体相互作用.
研究的目的:
- 调查与特有病原体的共同进化如何影响一般耐药性.
- 确定共进化的对宿主对外来病原体脆弱性的影响.
- 探索宿主耐药性的遗传多样性的维持.
主要方法:
- 开发了一种具有可变重组的双位元遗传模型.
- 集成的一般和特定的阻力机制.
- 分析了同进化动态对阻力位置的影响.
主要成果:
- 同进化扩大了一般耐药性进化的条件,减少了外来病原体入侵风险.
- 同进化促进了抵抗位点的多态性,增加了宿主遗传多样性.
- 遗传多样性往往导致对外国和特有病原体的耐药性之间的正相关性.
结论:
- 与特有病原体共同进化的动态显著影响宿主耐药性结构.
- 宿主对外来病原体溢出影响的易感性是通过共同进化调节的.
- 抗性成本和基因链接影响共同进化过程的结果.
相关概念视频
Infection
8.1K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.1K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Gene Flow
35.2K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.2K
Development of Antibiotic Resistance
40
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
40
Antibiotic Selection
54.7K
Overview
54.7K
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K


