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Updated: Jul 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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错误拼接导致p53的功能丧失E224D 点位突变

Ian C Lock1, Nathan H Leisenring2,3, Warren Floyd1,4

  • 1Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

bioRxiv : the preprint server for biology
|August 14, 2023
PubMed
概括

矛盾的是,TP53基因p53E221D的一个特定突变导致了瘤抑制的丧失. 这种TP53突变导致RNA拼接错误,导致非功能性p53蛋白和癌症风险增加.

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