饮食,血葡萄糖和脊椎动物癌症患病率之间的关系
Stefania E Kapsetaki1,2,3, Anthony J Basile4,5, Zachary T Compton1,2
1Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.
bioRxiv : the preprint server for biology
|August 14, 2023
概括
较高的平均血葡萄糖度 (MPGluC) 与不同物种癌症患病率较低有关. 这可能是由于鸟类进化的胰岛素耐药性,促进长寿和减少瘤.
科学领域:
- 比较生物学是比较生物学.
- 进化医学是一种进化医学.
- 癌症研究 癌症研究
背景情况:
- 癌症的患病率在各个脊椎动物物种之间有很大差异.
- 在这种变化中,饮食和代谢因素 (如平均血葡萄糖度 (MPGluC)) 的作用尚未完全理解.
- 了解这些因素可以提供有关癌症演变和预防的见解.
研究的目的:
- 为了研究饮食,MPGluC和脊椎动物物种癌症/瘤患病率之间的关系.
- 确定MPGluC或热量水平是否是癌症患病率的显著预测因素.
- 探索潜在的进化机制,以观察到的相关性为基础.
主要方法:
- 从160种脊椎动物物种的现有数据库中编制了关于饮食,MPGluC和瘤的数据.
- 利用相关性分析来评估MPGluC,热量水平和癌症患病率之间的关系.
- 检查了关于MPGluC和热带水平的物种分布.
主要成果:
- MPGluC与癌症和瘤患病率有负相关性,特别是在胃肠道器官.
- 热量水平与癌症和瘤患病率正相关,独立于MPGluC.
- 鸟类主要具有高的MPGluC,而爬行动物和哺乳动物在高的食物营养水平中很常见.
结论:
- MPGluC和热量水平是影响跨物种癌症患病率的重要因素.
- 鸟类进化胰岛素耐药性可能解释了它们的较低瘤发病率,尽管MPGluC.
- 这些发现为癌症和长寿的进化驱动因素提供了新的视角.
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