前带状皮质的特殊作用,但不是轨道前皮质或底侧杏仁体,在涉及信息的选择中
bioRxiv : the preprint server for biology
|August 14, 2023
概括
鼠可能会为信息付费,但抑制前带皮层 (ACC) 会扰乱雌性这种选择. 这表明ACC在涉及信息搜索的决策中扮演了性别依赖的角色.
科学领域:
- 神经科学是一个神经科学.
- 决策方式 决策方式
- 动物行为 动物行为
背景情况:
- 实验对象通常会为获取信息而承担成本.
- 悖论性选择程序涉及权衡具有不确定性和某些结果的选择.
- 皮质-桃体电路与基于价值的决策有关.
研究的目的:
- 研究特定大脑区域在信息偏好中的因果作用.
- 确定前带状皮质 (ACC),轨道前皮质 (OFC) 或底侧杏仁体 (BLA) 是否对寻找信息的决策至关重要.
- 检查信息偏好背后的神经机制中的性别差异.
主要方法:
- 利用抑制性DREADDs在雄性和雌性大鼠的ACC,OFC和BLA中选择性抑制神经活动.
- 在一项任务中评估选择行为,老鼠在具有不同信息内容和奖励概率的选项之间进行选择.
- 使用后勤回归分析行为数据,以确定预测选择偏好的因素.
主要成果:
- 抑制ACC使选择偏好不稳定,特别是在雌性大鼠中.
- 在ACC抑制后,没有观察到对选择延迟或暗示响应率的显著影响.
- 具有ACC抑制的对照动物和雄性老鼠显示出先前选择预测的选择偏好,与具有ACC抑制的雌性不同.
结论:
- 前带状皮质 (ACC) 在涉及寻求信息的决策中起因性,性别依赖的作用.
- 对于信息偏好的神经机制在雄性和雌性大鼠之间有所不同.
- 这些发现凸显了ACC在受信息价值影响的复杂决策过程中的重要性.
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