在反复网络中,Feedforward放大是矛盾的神经编码的基础.
bioRxiv : the preprint server for biology
|August 14, 2023
概括
运动皮层中的神经活动会影响行为,但机制尚不清楚. 这项研究揭示了前侧运动皮质 (ALM) 中的一种放大送电路,该电路将小的神经信号转化为重要的行为选择.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 计算神经科学是一种神经科学.
背景情况:
- 单个神经元活动编码行为变量,如感官刺激和选择.
- 神经活动对行为结果的确切影响仍然在很大程度上是未知的.
- 了解神经动力学对于破译大脑功能至关重要.
研究的目的:
- 用前侧运动皮层 (ALM) 的记录来估计神经活动对行为选择的影响.
- 研究神经选择选择性和行为影响之间的关系.
- 识别负责将神经信号转化为行为的潜在电路机制.
主要方法:
- 在ALM中记录了小鼠执行记忆引导运动任务的神经活动.
- 从神经活动记录中估计的行为影响.
- 利用有针对性的光刺激来探测神经活动和行为之间的因果关系.
主要成果:
- 选择选择性通过神经活动空间中的顺序方向增加.
- 早期的神经活动方向具有较低的选择性,但具有较高的预测行为影响;晚期方向显示相反.
- 沿着早期方向的活动触发了连续的活动,并导致可预测的行为偏差,与前放大一致.
结论:
- 在运动皮层中展示了一种放大前动态图案.
- 解释了在扰动实验中观察到的矛盾反应.
- 揭示了微妙的,小幅度的神经动态的行为相关性.
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