慢性血栓栓塞性肺高血压的特定个体的一维流体动力学模型
Amirreza Kachabi1, Mitchel J Colebank1, Naomi Chesler1
1University of California, Irvine.
Research square
|August 14, 2023
概括
慢性血栓栓塞性肺高血压 (CTEPH) 增加了肺动脉的硬度,并改变了血液流动的动态. 这项研究模拟了这些变化,以预测疾病进展,并为CTEPH患者指导向治疗.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
背景情况:
- 慢性血栓栓塞性肺高血压 (CTEPH) 是由肺动脉堵塞引起的,导致压力增加.
- 由于测量挑战,对CTEPH进展的机械生物学驱动因素的了解很少.
- 肺血管系统的血液动力学和机械变化至关重要,但很难量化.
研究的目的:
- 研究CTEPH对肺动脉硬化,壁切应力和流动振荡的影响.
- 开发特定学科的计算流体动力学 (CFD) 模型来分析CTEPH血动力学.
- 为了确定预测CTEPH进展的潜在生理标志物.
主要方法:
- 利用CTEPH大型动物模型的已发表的血液动力学和成像数据.
- 开发了特定的主题的一维 (1D) 计算流体动力学 (CFD) 模型.
- 分析了肺动脉壁硬度的变化,时间平均壁剪应力 (TAWSS) 和振荡剪指数 (OSI).
主要成果:
- CTEPH显著增加了肺动脉壁的硬度.
- 在主要和小型肺动脉中,CTEPH降低了TAWSS.
- CTEPH提高了动脉网络中呈现低TAWSS和高OSI的比例.
结论:
- 实验计算框架准确地模拟了CTEPH引起的血液动力学和机械变化.
- 这种方法可以通过识别关键生理标志物,如低TAWSS和高OSI来预测疾病的进展.
- 这些发现支持为个人CTEPH患者开发空间定向干预措施.
相关概念视频
01:30Venous Thrombosis I: Introduction
12
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
12
00:57Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
115
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
115
01:29Pulmonary Embolism I: Introduction
7
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
7
01:30Pulmonary Hypertension: Classification and Pathogenesis
223
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
223
01:30Typical Model Studies
382
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
382
01:09The Buckingham Pi Theorem
730
The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.
730