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Updated: Jul 19, 2025

Quantitative Phosphoproteomics in Fatty Acid Stimulated Saccharomyces cerevisiae

Quantitative Phosphoproteomics in Fatty Acid Stimulated Saccharomyces cerevisiae

Published on: October 12, 2009

平行蛋白质组学和蛋白质组学定义了细胞静止中的饥饿信号特定过程

Siyu Sun^1,2, Daniel Tranchina^2,3, David Gresham^1,2

¹Center for Genomics and Systems Biology.

bioRxiv : the preprint server for biology

|August 14, 2023

概括

营养缺乏会通过明显的蛋白质和酸化变化引发细胞静止. 激酶RIM15在特定的饥饿条件下对生存起着关键作用,影响RNA代谢和翻译.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
生物化学生物化学

背景情况:

当营养物质稀缺时,细胞进入静止状态.
细胞在应对不同饥饿信号时进入静止状态的分子机制尚未完全理解.

结论:

定义了酵母酵母中的扩展静止蛋白质和蛋白质.
突出了蛋白质表达和酸化在建立静态状态中的协调作用.
通过不同的饥饿信号激活的明显和共同的分子通路.

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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...