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Updated: Jul 19, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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结构信息化蛋白质语言模型是对变异效应的可靠预测器

Yuanfei Sun1, Yang Shen1,2,3

  • 1Department of Electrical and Computer Engineering, Texas A&M University, College Station, 77843, Texas, USA.

Research square
|August 14, 2023
PubMed
概括

结构信息化的蛋白质语言模型 (SI-pLMs) 通过结合结构上下文来改善变异效应预测. 这种方法提高了不需要实验标签的准确性,克服了仅序列模型的局限性.

关键词:
变量效应预测变量效应的预测.多模式机器学习.蛋白质语言模型的模型蛋白质序列中的蛋白质序列.蛋白质结构 蛋白质结构

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