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Updated: Jul 19, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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通过一种新的方法来改善遗传关联研究,揭示了所有原因心力衰竭的隐藏复杂性

John T Gregg1, Blanca E Himes1, Folkert W Asselbergs2

  • 1Department of Biostatistics Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

medRxiv : the preprint server for health sciences
|August 14, 2023
PubMed
概括

综合效应的转化回归分析 (TRACE) 通过计算临床异质性和识别基因与环境相互作用来改进全基因组关联研究 (GWAS),显著增加了解释心力衰竭等复杂疾病的差异.

关键词:
在GWAS中,GWAS就是GWAS.生物信息学是一种生物信息学.计算生物学是计算生物学.功能工程的特点工程.机器学习是机器学习.

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