Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Efficacy of psychological interventions for adolescents with borderline personality disorder: a systematic review and meta-analysis.

Frontiers in psychiatry·2026

Same author

A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.

EBioMedicine·2026

Same author

Macrophage-mediated brain-bone marrow crosstalk promotes chronic stress-induced glioma growth.

Cancer cell·2026

Same author

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes.

Research square·2026

Same author

Heterogeneous causal mediation analysis using Bayesian additive regression trees.

Biometrics·2026

Same author

2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: Jul 19, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

scMD:使用单细胞DNA甲基化参考进行细胞类型解.

Manqi Cai¹, Jingtian Zhou^2,3, Chris McKennan⁴

¹Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.

bioRxiv : the preprint server for biology

|August 14, 2023

概括

此摘要是机器生成的。

我们开发了scMD,这是一种用于单细胞DNA甲基化解缩的新型计算框架. scMD从大量DNA甲基化数据中准确估计细胞类型分数,为复杂组织推进表观基因组分析.

科学领域:

表观基因组学是指表观基因组学.

更多相关视频

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

相关实验视频

Last Updated: Jul 19, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

计算生物学计算生物学

细胞生物学细胞生物学

背景情况:

单细胞RNA测序已经使转录组数据的细胞解卷成为可能,但缺乏用于DNA甲基化的类似方法.
单细胞DNA甲基化 (scDNAm) 数据由于其高维度和稀疏性而带来挑战,特别是在像大脑这样的组织中.
现有的scDNAm分析方法在不完整的基因组覆盖率和细胞间不同的检测区域方面扎.

结论:

scMD能够从大量的DNA甲基化数据中准确地估计细胞类型分数,这对于表观遗传学研究至关重要.
scMD的应用揭示了与阿尔茨海默病相关的细胞类型分数和细胞类型特异性甲基化细胞蛋白.
这项工作为分析缺乏细胞类型参考的复杂组织中的DNA甲基化开辟了新的途径.