尿液双A与男性精液参数的相关性 转到不孕中心:一个横截面研究
Mir Mohammad Reza Aghajani1, Hamid Shafi1, Maryam Gholamitabar Tabari2
1Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
International journal of fertility & sterility
|August 14, 2023
概括
这项研究发现,尿液中的双甲 (BPA) 含量与男性不孕不育之间没有显著的联系. 虽然有些男性有可检测的BPA,但它没有影响精子参数或整体生殖激素.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 内分泌学 在内分泌学.
背景情况:
- 双A (BPA) 是一种内分泌干扰物,已知具有不良健康影响.
- 在各种工业产品中普遍存在BPA,这引发了对人类暴露的担忧.
- 在寻求不孕症治疗的男性中评估BPA水平对于了解潜在的环境影响至关重要.
研究的目的:
- 评估参加不孕症诊所的男性的双甲 (BPA) 尿度.
- 调查BPA暴露与无育男性的精液参数和生殖激素之间的关系.
- 为了确定BPA水平是否与男性不孕症有关.
主要方法:
- 一项涉及122名不育夫妇的男性伴侣在伊朗马桑达兰进行的横截面研究.
- 数据收集包括关于人口统计,病史和生活方式的问卷,以及体检.
- 高性能液体染色学 (HPLC) 用于量化点尿样中的BPA水平.
主要成果:
- 在53.3%的尿样中没有检测到双甲 (BPA).
- 在尿液中的BPA度与精液参数或男性生殖激素之间没有发现显著的关系.
- 观察到可检测的BPA和精子度之间的潜在反向关联,尽管在所有参数上都没有统计学意义.
结论:
- 大多数参与者在尿液中表现出不可检测的BPA水平,这表明该地区的环境暴露可能较低.
- 在这个研究群体中,BPA水平和男性不孕不育之间没有建立总体关联.
- 需要进一步的研究来探索BPA暴露的区域差异及其对男性生殖健康的长期影响.
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