相关实验视频
Updated: Jul 19, 2025

08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
14.4K
老年人的亚临床左心室功能障碍和心室节律失常,具有正常的喷射分数
Yuriko Yoshida1, Zhezhen Jin2, Koki Nakanishi3
1Department of Medicine Columbia University New York NY.
Journal of the American Heart Association
|August 14, 2023
概括
亚临床左心室 (LV) 功能障碍,由减少的全球纵向应变 (GLS) 表示,与老年人频繁的早发性心室收缩 (PVC) 和非持续性心室低心率 (NSVT) 有关. 这种早期的关联表明了对心室心律失常的预防策略的潜力.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 早发性心室收缩 (PVC) 和非持续性心室低心率 (NSVT) 与结构性心脏病患者的排气分数减少和不良结果有关.
- 在一般人群中,亚临床LV功能障碍和心室节律失常之间的关联仍然不清楚.
研究的目的:
- 为了研究亚临床左心室 (LV) 功能障碍与老年社区群体中心室失律的发生之间的关系.
- 为了确定是否减少LV全球纵向应变 (GLS) 与常见的PVC和NSVT有关,在正常LV射出分数的个体中.
主要方法:
- 在SAFARIS研究中分析了503名参与者 (平均年龄77岁,63%是女性) 的数据,这些参与者具有正常的LV射出分数.
- 14天的心电图监测,以识别频繁的PVC (>500/24h) 和NSVT (≥4次连续的室内外皮跳).
- 2D回声心动图以评估LV全球纵向应变 (GLS) 作为亚临床LV功能障碍的标志物.
主要成果:
- 15.1%的参与者有频繁的PVC,而23.3%的人有NSVT发作.
- 减少的LV GLS与频繁的PVC和NSVT显著相关.
- 下方LV GLS独立预测了常见的PVC (aOR 1.19) 和NSVT (aOR 1.09).
- 异常的LV GLS (>-15.8%) 对PVC和NSVT的风险增加了两倍.
结论:
- 包括PVC和NSVT在内的心室心律不整,在老年人中常见,他们的LV射出分数正常.
- 亚临床 LV 功能障碍,以减少 GLS 为证据,与这些心室心律失常独立相关.
- 这些发现突显了LV功能障碍和心室节律失常之间早期的亚临床联系,表明了预防性干预的潜力.
相关概念视频
Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
Mitral Regurgitation I: Introduction
17
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
17
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Heart Failure III: Clinical Manifestations
23
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
23
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
23
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
23
Cardiomyopathy III: Hypertrophic Cardiomyopathy
16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16

