一个基于voxel和源的形态学分析灰色物质体积差异在非常晚发的精神分裂症类精神病
Lies Van Assche1,2, Akihiro Takamiya2,3, Jan Van den Stock1,2
1Geriatric Psychiatry, University Psychiatric Center KU Leuven, Leuven, Belgium.
Psychological medicine
|August 14, 2023
概括
非常晚发的精神分裂症类精神病 (VLOSLP) 与体和前部区域灰质体积的减少有关. 这种大脑结构的差异可能解释了VLOSLP.在老年人中观察到的记忆障碍.
科学领域:
- 神经成像和精神病学研究
- 神经退行性疾病 神经退行性疾病
- 老年医学 老年医学
背景情况:
- 非常晚发精神分裂症类精神病 (VLOSLP) 在老年人群中构成了越来越大的挑战.
- 关于VLOSLP的神经生物学基础的研究有限,这阻碍了有效的管理.
- 了解大脑结构的差异对于解决老年人VLOSLP负担至关重要.
研究的目的:
- 为了研究与健康对照人群相比,VLOSLP患者的灰质体积 (GMV) 差异.
- 探索在VLOSLP中GMV变化和认知功能之间的关系.
- 为了阐明神经生物学基础非常晚发症的精神分裂症类似的精神病.
主要方法:
- 横截面研究比较了35名VLOSLP患者和36名健康对照.
- 在MRI扫描中使用全脑基于素的形态测量 (VBM) 和基于源的形态测量 (SBM).
- 使用全面的神经心理学电池评估认知功能.
主要成果:
- 在VLOSLP患者的体内表现出较低的GMV在丘脑,左下额头,和左侧胰岛 (VBM).
- 基于来源的形态测量显示,在VLOSLP组中,thalamo-temporal GMV减少.
- 认知功能受损包括处理速度,注意力,记忆和命名;在VLOSLP患者中,乳头体积与记忆相关.
结论:
- 胸膜和前额部区域灰质体积的减少与VLOSLP相关.
- 下丘脑的GMV可能直接导致非常晚发的精神分裂症类精神病的记忆缺陷.
- 这些发现提供了对晚发性精神病和相关认知衰退的神经生物学的见解.
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