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相关概念视频

RNA Structure01:19

RNA Structure

4.9K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
4.9K
RNA Stability01:53

RNA Stability

33.7K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.7K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.2K
Nucleic Acids02:43

Nucleic Acids

44.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.3K
Nucleic acids02:43

Nucleic acids

163.7K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
163.7K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

14.2K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
14.2K

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相关实验视频

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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配列依赖性RNA双重复的属性

Federica Battistini1,2, Alba Sala1, Adam Hospital1

  • 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, Barcelona 08028, Spain.

Journal of chemical information and modeling
|August 14, 2023
PubMed
概括

与DNA复合体相比,RNA复合体表现出明显的弹性特性,挑战了刚性杆模型. 这项研究揭示了RNA.

科学领域:

  • 生物物理学的生物物理.
  • 计算生物学 计算生物学
  • 结构生物学 结构生物学

背景情况:

  • 通过分子动力学模拟,DNA双重性质得到了很好的定义.
  • 由于缺乏详细的模拟数据,RNA复合体经常被过度简化为刚性棒.
  • 了解RNA机制对于其多样化的生物功能至关重要.

研究的目的:

  • 用广泛的模拟来描述RNA复合体的依赖序列的弹性特性.
  • 开发一个用于预测长RNA复合体的机械行为的美索斯科普模型.
  • 在基本层面上比较RNA和DNA复合体的弹性特性.

主要方法:

  • 大规模分子动力学模拟ABC优化的RNA复杂体.
  • 导出RNA复合体的四聚体分辨率特性.
  • 开发一种简单的 RNA 双重弹性的美索斯科普模型.

主要成果:

  • RNA复合体表现为弹性系统,与DNA复杂的灵活性不同.
  • 通过使用波潜能,可以准确地建模RNA复合体中的变形.
  • 基因内部和基因间对参数,以及运动相关性,在RNA和DNA复杂体之间都有显著差异.
  • 序列和变形类型极大地影响RNA和DNA双重复杂的灵活性和稳定性.

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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

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结论:

  • 对于RNA复杂体的简化刚性棒模型是不够的.
  • 与DNA相比,RNA复合体具有明显的弹性特性,需要对序列进行特定分析.
  • 一个新的中视镜模型为理解长RNA双重力学提供了一个框架.