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对皮肤黑色素瘤和瘤微环境状态的与烧灭相关的 lncRNA 预后签名

Huiling Deng¹, Yuxuan Chen¹, Ran An¹

¹Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

|August 14, 2023

概括

这项研究确定了八种与灭相关的长非编码RNA (lncRNAs),它们影响皮肤黑色素瘤 (CM) 患者的预后和抗瘤免疫力. 使用这些lncRNAs的新风险模型预测了患者的存活率,并建议CM.新的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

皮肤黑色素瘤 (CM) 的预后和治疗仍然具有挑战性.
与烧灭相关的长非编码RNAs (lncRNAs) 与各种癌症有关.
在CM中与热相关的lncRNAs的作用需要进一步研究.

研究的目的:

探索皮肤黑色素瘤中与热死相关的lncRNAs的预后价值.
建立基于与火死相关的 lncRNAs 的CM患者的预后风险模型.
评估风险模型与CM中的抗瘤免疫之间的关联.

主要方法:

进行了生物信息分析,以确定关键的灭与相关的 lncRNAs.
使用选择的 lncRNAs 构建了一个预后风险模型.
进行了与免疫相关的分析,以评估该模型与免疫状态和瘤微环境的相关性.

主要成果:

鉴定出8种与火死相关的lncRNA与CM预后有显著关联.
建立了一个预后风险模型,将患者分为低风险和高风险组.
低风险组的总体存活率明显更高.

结论:

开发的预后风险模型准确地预测了CM患者的生存结果.
与烧死相关的 lncRNAs 提供了作为CM预后生物标志物的潜力.
这些lncRNAs可能代表皮肤黑色素瘤的新疗法标.

关键词:

这是皮肤黑色素瘤.在 lncRNAs 中.预后预后预后热致灭症是什么?瘤微环境是一个微环境.

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