与异性性别女性相比,在未使用过毒品的跨性别男性中,与高雄性相关的代谢变化:一项病例对照研究
Pınar Erel1, Onur Elbasan2, Neşe Yorguner3
1Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Türkiye.
Endokrynologia Polska
|August 14, 2023
概括
与女性相比,吸毒的跨性别男性表现出更高的雌激素水平和代谢变化. 需要进一步的研究,以了解这种人群中高雄性质的原因.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 性别研究是性别研究.
背景情况:
- 性别失调症的病因仍然不清楚.
- 之前对跨性别男性雄激素水平的研究使用了未经选择的人群.
- 这项研究侧重于选定的一组未曾使用过毒品的人群.
研究的目的:
- 评价和比较药物素朴的跨性别男性与 cisgender 妇女的荷尔蒙特征和代谢状态.
- 为了调查人体测量,代谢和内分泌学参数.
- 这是同类型的第一个病例控制研究.
主要方法:
- 单中心观察队列研究.
- 纳入了70名未曾吸毒过的跨性别男性和34名健康的女性.
- 测量和比较荷尔蒙配置文件和代谢参数.
主要成果:
- 与 cisgender 女性相比,跨性别男性的总体,自由雄激素指数,androstenedione,17-hydroxyprogesterone,肌肉强度,甘油三和胰岛素抵抗水平更高.
- 16名跨性别男性 (22.85%) 被诊断患有多囊性卵巢综合征 (PCOS),而对照组中有4名 (11.7%).
- 即使在排除PCOS患者后,跨性别男性中也明显出现过高雄性.
结论:
- 跨性别男性表现出明显更高的雄激素水平比 cisgender 女性.
- 较高的雄激素水平可能导致观察到的代谢变化.
- 药物素朴的跨性别男性中高雄性质的主要原因需要进一步调查.
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