在40年的时间内,无食症神经病患者的骨折风险超过40年
Mette Søeby1,2,3, Sigrid Bjerge Gribsholt1,2, Loa Clausen4,5
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
概括
神经性厌食症 (AN) 患者在诊断后的40年内面临46%更高的骨折风险,特别是在脊椎和大腿骨中. 近几十年来,这种风险已经下降,这表明AN的检测和治疗得到了改进.
科学领域:
- 骨和矿物质研究研究
- 临床内分泌学 临床内分泌学
- 公共卫生 公共卫生
背景情况:
- 神经性厌食症 (AN) 与骨折风险增加有关,但长期数据和性别特异性影响需要进一步调查.
- 了解AN患者骨折风险的时间趋势对于有效的临床管理和公共卫生策略至关重要.
研究的目的:
- 评估与相匹配的一般人群队列相比,与AN患者的长期骨折风险 (长达40年) 相比.
- 研究年龄,性别和与时间相关的变化对AN患者骨折风险的影响.
主要方法:
- 利用丹麦医疗保健登记册识别了1977年至2018年间诊断的14414名AN患者.
- 采用考克斯回归分析来计算整体和特定部位骨折的调整危险比率 (aHR).
- 分析了不同时期的骨折风险,以确定趋势.
主要成果:
- AN与46%的任何骨折风险增加有关 (aHR=1.46).
- 患有AN的女性的整体骨折风险 (aHR=1.50) 比男性 (aHR=0.95) 高.
- 对大腿骨 (女性:aHR=4.06;男性:aHR=2.79) 和脊椎骨折 (女性:aHR=2.38;男性:aHR=2.31) 观察到高位特异性风险.
- 整体骨折风险 (aHR) 从1.66 (1977-1997) 降至1.40 (1998-2018) 的水平.
结论:
- 神经性厌食症显著增加了长期骨折的风险,特别是在脊柱和股骨,与显著的性别差异.
- 随着时间的推移,观察到的骨折风险下降表明,改善AN的诊断和管理可能会减轻骨并发症.
- 持续的研究和临床警是必要的,以解决AN患者持续的骨脆弱性.
相关概念视频
01:28Anorexia Nervosa
147
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
147
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:30Bulimia Nervosa
161
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
161
01:27Fractures: Bone Repair
3.3K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.3K
01:09Changes in the Appendicular Skeleton with Age
2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K
01:23Binge Eating Disorders
145
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
145