在患有急性细菌性鼻炎的患者中,抗生素敏感性和鼻腔微生物群
Ho-Jin Gwak1, Hyeon A Lee2, Jae Yeong Jeong2
1Department of Computer Science, Hanyang University, Seoul, Korea.
The Laryngoscope
|August 14, 2023
概括
在急性细菌性鼻炎 (ABRS) 中,鼻腔微生物组显示了较低的Lactobacillaceae. 抗生素的使用没有显著改变ABRS微生物群,但耐药性与特定的细菌变化有关.
科学领域:
- 微生物学 微生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 急性鼻炎 (ARS) 是一种常见的感染,通常是病毒性感染,在急性细菌性鼻炎 (ABRS) 中对鼻子微生物群的理解有限.
- 研究鼻腔微生物组在ABRS中的作用及其对抗生素的反应对于有效的治疗策略至关重要.
研究的目的:
- 与健康对照人群相比,对患有ABRS患者的鼻腔微生物群进行表征.
- 为了评估ABRS的抗生素治疗后鼻子微生物组的变化.
- 为了确定与抗生素耐药性相关的微生物差异在ABRS.
主要方法:
- 未来单中心研究涉及43名ARS患者和5名健康对照.
- 用细菌培养,抗菌素敏感性测试和16S rRNA测序分析的鼻腔样本 (中间肉类粘液).
- 在13名ABRS患者呈现时和经过1周的阿莫西西林 - 克拉夫兰酸治疗后采集的样本.
主要成果:
- 与健康对照组相比,ABRS患者的乳酸菌家族丰度明显较低.
- 抗生素治疗没有显示出中间肉体微生物组的显著变化.
- 抗生素耐药的ABRS病例与较低的乳酸细菌,增加的病原体 (Rhodococcus,Massila,Acinetobacter,H. influenza) 和更高的β多样性有关.
结论:
- 乳酸菌家族在ABRS中发挥作用.
- 在ABRS.中,Acinetobacter和Massilia物种与阿莫西西林耐药性有关.
- 在ABRS中,鼻子微生物组的组成不同于健康个体,并且在抗生素治疗后显示出有限的变化.
更多相关视频
09:02Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
1.5K
09:12Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
12.5K
相关概念视频
01:20Sputum Studies II: Culture and Sensitivity
395
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
395
01:26Urine Studies II: Urine Culture and Sensitivity Test
55
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
55
01:16Drugs Used in Upper Respiratory Disorders: Overview
290
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
290
01:30Acute Pharyngitis
845
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
845
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
17
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
17