在成年人一生中,单个主体的皮质形态大脑网络跨越了成年人寿命
Jingxuan Ruan1, Ningkai Wang2, Junle Li2
1School of Electronics and Information Technology, South China Normal University, Foshan, China.
Human brain mapping
|August 14, 2023
概括
大脑网络在皮质厚度上显示出与年龄相关的显著重组,特别是在额头区域和短距离连接中. 这些变化影响认知,并解释了认知衰老中的个体差异.
科学领域:
- 神经科学是一个神经科学.
- 大脑衰老研究研究
- 网络科学 网络科学
背景情况:
- 已知焦点皮质形态的与年龄相关的变化.
- 皮层形态学与年龄之间的区域间协调模式的重组是不太了解的.
研究的目的:
- 在成年人一生中全面分析单个主体形态大脑网络的拓变化.
- 通过使用线性,二次性和立方体模型,研究网络测量的与年龄相关的变化.
主要方法:
- 为650名参与者 (18-88岁) 构建了四种单个对象形态大脑网络.
- 使用基于图形的网络测量方法来描述网络拓.
- 使用线性,二次性和立方模型检查了与年龄相关的变化.
主要成果:
- 在全球网络属性,效率,局部节点中心性和区域间相似性方面发现了与年龄相关的深刻变化.
- 在皮层厚度网络,额头区域和短距离连接中,变化很突出,经常显示出线性趋势.
- 在岛屿和边缘区域观察到非线性变化 (四度/立方),立方变化有利于长距离连接.
结论:
- 额头区域之间皮质厚度的形态相似性介导了年龄和认知之间的关系.
- 这些发现加深了对随着衰老和个体认知变异而发生的适应性大脑变化的理解.
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