(S) - 胺但不是 (R) - 胺对老鼠的抑郁症行为和睡眠-觉醒架构表现出急性影响
Szabolcs Koncz1, Noémi Papp1, Dóra Pothorszki1
1Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
The international journal of neuropsychopharmacology
|August 14, 2023
概括
与 (R) 胺不同的是, (S) 胺反体显著改变睡眠模式,并在老鼠中表现出抗抑郁作用. 这表明 (S) - 胺.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
背景情况:
- 种族类胺含有具有不同特性的 (R) 和 (S) -enantiomers.
- (S) 胺被批准用于抑郁症; (R) 胺缺乏已证明的抗抑郁作用.
- 重度抑郁症通常涉及睡眠中断,包括快速眼动 (REM) 和非REM (NREM) 睡眠.
研究的目的:
- 为了比较 (R) - 和 (S) - 胺基因对大鼠睡眠-觉醒阶段的急性影响.
- 在压力诱导的抑郁模型中评估每个反体的抗抑郁类活性.
主要方法:
- 输入量为15 mg/kg,每次输入量为15 mg/kg. 每个胺反体的自由移动,装有EEG的老鼠.
- 评估睡眠-清醒阶段和电脑电图 (EEG) 功率谱.
- 利用强迫游泳测试来评估慢性压力大鼠的抗抑郁药类效应.
主要成果:
- (S) 胺增加了REM睡眠延迟时间,并减少了REM睡眠持续时间.
- (S) 胺提升了NREM睡眠EEG三角力和增加了清醒,同时减少了NREM睡眠.
- 在强迫游泳测试中, (S) - 胺减少了不运动时间,表明了类似抗抑郁药的活性; (R) - 胺没有.
结论:
- (R) - 和 (S) - 胺对睡眠-清醒结构和行为的影响在相同剂量下显著不同.
- (S) 胺对睡眠-清醒周期的影响和潜在的睡眠相关的神经可塑性可能是其抗抑郁药疗效的基础.
- 观察到的 (R) - 胺缺乏作用与最近的临床发现一致.
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