化学抗原受体T细胞治疗模式在复发性或耐火性大B细胞淋巴瘤中
Roxanna Seyedin1, Julia T Snider2, Krithika Rajagopalan1
1Anlitiks Inc., Windermere, FL 34786, USA.
Future oncology (London, England)
|August 14, 2023
概括
医生正在选择较低风险的患者进行门诊化学抗原受体 (CAR) T细胞治疗. 然而,即使是门诊输液的患者也经历了大量的输液后住院治疗,这表明在管理CAR T细胞治疗方面存在持续的挑战.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 化学抗原受体 (CAR) T细胞疗法在治疗血液恶性瘤方面取得了重大进展.
- 了解现实世界的治疗模式对于优化患者护理和资源配置至关重要.
研究的目的:
- 调查复发/耐药大B细胞淋巴瘤患者的真实世界CAR T细胞疗法治疗模式.
- 评估与CAR T细胞治疗相关的患者特征,输液设置,不良事件和医疗资源利用情况.
主要方法:
- 对1175名患有复发性/耐药性大B细胞淋巴瘤的患者进行了回顾性分析,这些患者接受了CAR T细胞治疗.
- 评估患者人口统计,输液设置 (住院或门诊),CAR T 细胞治疗相关的不良事件和医疗保健资源利用情况.
主要成果:
- 大多数患者 (83%) 在住院治疗中接受了CAR T细胞治疗.
- 住院输液患者在输液后三天内面临与CAR T细胞治疗相关的不良事件的风险显著增加 (HR:2.67).
- 尽管进行了门诊输液,但67%的患者在第30天需要住院治疗.
结论:
- 医生擅长识别低风险患者适合门诊CAR T细胞治疗输液.
- 输液后住院仍然是一个常见的现象,即使是门诊治疗的患者,强调需要持续监测和管理策略.
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