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MRAβ:阿尔茨海默病的多式MRI衍生的粉样β生物标志物

Yu Zhang¹, Xi Li^1,2, Yi Ji¹

¹Department of Radiology and Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.

Human brain mapping

|August 14, 2023

概括

一种新的多模式MRI衍生生物标志物 (MRAβ) 能够有效地模仿阿尔茨海默病的粉样蛋白-β PET成像 (AV45),为诊断和预测提供一种无辐射,具有成本效益的替代方案.

科学领域:

神经成像是一种神经成像.
生物标志物开发生物标志物开发
人工智能在医学中的应用

背景情况:

佛罗贝塔皮尔F (AV45) PET成像是阿尔茨海默病 (AD) 粉样β敏感生物标志物,但受到辐射暴露和成本的限制.
开发非辐射,具有成本效益的生物标志物对于广泛的AD诊断和监测至关重要.

研究的目的:

使用协作生成对抗网络 (CollaGAN) 模型开发一种来自MRI的多式Amyloid-β (MRAβ) 生物标志物.
评估MRAβ模仿AV45 PET成像的能力及其在区分阿尔茨海默病和轻度认知障碍与健康对照的诊断性能.

主要方法:

收集了来自ADNI数据集中的380名参与者和OASIS3数据集中的64名参与者的多式MRI和AV45 PET数据.
应用了五倍交叉验证的CollaGAN模型,从多模式MRI数据中生成MRAβ.
使用voxel-wise t测试和3D ResNet分类器来评估MRAβ的准确性和与AV45.5的可比性.

主要成果:

在AD和MCI患者中,MRAβ成功地表征了主体级AV45空间变异.
在AD和MCI中由MRAβ识别的粉样β沉积量明显高于健康对照组,与AV45发现高度相关 (r > .92).
在区分AD与健康对照和MCI与健康对照方面,MRAβ的表现与AV45相似.

结论:

多模态MRI衍生的MRAβ可以有效地模仿AV45 PET成像检测到的大脑粉样β沉积物.
作为阿尔茨海默病的无辐射,具有成本效益的分子可解释的生物标志物,MRAβ显示出前景.
这种方法支持MRI技术的进步,用于神经退行性疾病中的分子生物标志物应用.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.粉样化物-β-β 的存在.花是泰皮尔的花.生成性的对抗性网络.磁共振成像技术的使用定子发射断层扫描 (PET).

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