数字认知行为治疗阿托皮性皮肤炎的疗效和相关神经递质:一项比较有效性研究
Wanying Zhai1, Rui Tang1, Yali Gao1
1Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Asian Pacific journal of allergy and immunology
|August 14, 2023
概括
数字认知行为疗法 (dCBT) 有效地减少负面情绪,改善皮炎 (AD) 症状,如和失眠. 这种方法也可能改变与情绪相关的神经递质,作为治疗疗效的生物标志物.
科学领域:
- 皮肤病学 皮肤病学
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 负面情绪经常与亚托皮性皮肤炎 (AD) 一起发生.
- 对于数字认知行为疗法 (dCBT) 作为AD的有效辅助剂的证据有限.
- 调查dCBT的疗效和相关生物标志物的研究对于管理伴随疾病的条件至关重要.
研究的目的:
- 评估dCBT作为AD患者经历负面情绪的辅助治疗的初步疗效.
- 为了识别潜在的神经递质生物标志物与治疗反应相关的AD与情绪伴随性疾病.
- 探索dCBT对临床症状和神经递质特征的影响.
主要方法:
- 32名患有轻度至中度负面情绪的AD患者被纳入.
- 参与者接受了标准护理或标准护理以及移动应用程序提供的dCBT,持续了12周.
- 使用LC-MS治疗前后分析了血神经递质水平 (40).
主要成果:
- 两组人都在皮肤病变,和失眠方面显著改善.
- 该dCBT加标准护理组在和失眠方面表现出更强大的改善.
- 三素,多巴胺和胺通路发生变化;dCBT后 taurine 增加;L-tyrosine 与症状减少相关.
结论:
- dCBT是阿尔茨海默病与负面情绪的有效补充治疗.
- 与情绪相关的神经递质可能在阿尔茨海默症的发病过程中发挥作用,并可能表明治疗的有效性.
- dCBT为管理AD的心理和身体症状提供了一个有希望的治疗途径.
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