脊椎骨质疏松症是否会延迟或加速腰椎盘退化? 一个系统的审查
Wenhao Li1, He Zhao2, Shibo Zhou1
1Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.
概括
脊椎骨质疏松症和椎间盘退化之间的关系受到争论,研究表明积极和消极的相关性. 需要更多的研究来澄清这种关联.
科学领域:
- 整形外科 整形外科 整形外科
- 老年学是一门学科.
- 类风湿病学 类风湿病学
背景情况:
- 脊椎骨质疏松症和椎间盘退化是常见的疾病,特别是在老年人群中.
- 这两个条件之间的相互作用仍然不完全理解,并且是正在进行的科学辩论的主题.
研究的目的:
- 系统地审查现有文献,阐明脊椎骨质疏松症和椎间盘退化之间的关系.
- 识别有关这种关联的当前研究发现的趋势和差异.
主要方法:
- 在电子数据库中进行了系统的文献搜索.
- 研究的选基于预定义的包含和排除标准.
- 数据的提取和总结遵循了系统审查和元分析 (PRISMA) 的首选报告项目指南.
主要成果:
- 总共分析了24年的34篇出版物,包括临床,尸体和动物研究.
- 临床研究显示了混合的结果,报告了积极的,负面的,没有相关性.
- 动物研究,特别是那些涉及抗骨质疏松症药物干预的动物研究,主要表明脊椎骨质疏松症和椎间盘退化之间存在积极联系.
结论:
- 虽然大多数研究都承认脊椎骨质疏松症与椎间盘退化之间存在关联,但关于这种关系的性质 (正或负) 有显著的分歧.
- 差异可能源于研究设计,观察期和随访时间的变化.
- 进一步进行全面的临床和基础研究是必不可少的,以确定脊椎骨质疏松症和椎间盘退化之间的关系.
相关概念视频
Structural Joints: Cartilaginous Joints
2.3K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.3K
General Structure of a Vertebra
3.0K
A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous...
3.0K
Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K


