患有慢性髓性白血病和冠状病毒病的患者2019年在奥米克朗时代
Feiyang Qi1, Mei Bao1, Hanlin Gao1
1Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, No. 11 Xizhimen South St, Beijing, 100044, China.
Annals of hematology
|August 14, 2023
概括
患有慢性髓性白血病 (CML) 的患者在Omicron大流行期间经历了高的COVID-19率. 年龄,并发症和城市生活等因素增加了风险,而较长时间的TKI治疗降低了风险. 心理健康受到重大影响,特别是在弱势群体中.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 对于患有慢性髓性白血病 (CML) 的患者来说,Omicron大流行带来了独特的挑战,这种情况需要长期的氨酸激酶抑制剂 (TKI) 治疗.
- 了解COVID-19感染,其严重程度和这种脆弱人群的心理健康结果之间的相互作用对于优化护理至关重要.
研究的目的:
- 在奥米克朗大流行期间调查CML患者中COVID-19感染的流行率和严重程度.
- 评估COVID-19对心理健康的影响,包括抑郁,焦虑和痛苦,在这个患者队列中.
- 确定与COVID-19感染和严重程度相关的风险因素,以及CML患者的不良心理健康结果.
主要方法:
- 在2609名被诊断患有CML的患者中进行了横截面调查.
- 收集的数据包括COVID-19感染状态,严重程度,心理健康评估 (抑郁,焦虑,痛苦,PTSD症状) 和人口/临床变量.
- 使用多变量分析来确定各种因素与COVID-19结果或心理健康状况之间的关联.
主要成果:
- 66%的CML患者报告COVID-19感染,主要是轻度 (94%).
- 观察到中度至重度抑郁症 (15%),焦虑症 (8%) 和痛苦 (20%) 的显著比例.
- 与更高的COVID-19患病率相关的因素包括城市生活和家庭感染. 增加年龄,并发症和对TKI治疗的耐药性与中度/严重的COVID-19有关.
- 女性性别,并发症,未接种疫苗状态,中度/重度COVID-19与不良心理健康结果有关. 随着年龄的增长和强制降低TKI剂量也与较差的心理健康相关.
结论:
- 在Omicron浪潮期间,CML患者面临着COVID-19的高负担,特定的人口和临床因素增加了风险.
- 心理健康的后果是常见的,这强调了需要综合护理,解决传染病和心理健康的问题.
- 较长的TKI治疗持续时间对COVID-19有保护作用,而年龄,并发病症和治疗耐药性等因素对严重疾病和心理健康下降造成了重大风险.
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