冠状病毒疾病2019 (COVID-19) 流行病生活方式的变化可能影响了小肠微生物组成和微生物耐药性
Ava Hosseini1, Mohamad Rashid1, Gabriela Leite1
1Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Digestive diseases and sciences
|August 14, 2023
概括
随着COVID-19的流行,健康个体的小肠微生物组发生了变化,极端动物的数量增加,阴性细菌的数量减少. 这些肠道微生物组的变化可能会影响人类健康.
科学领域:
- 微生物学 微生物学
- 人体生理学 人体生理学
- 肠道微生物组研究研究
背景情况:
- 在全球范围内,COVID-19大流行引发了重大的生活方式变化,影响了饮食,运动和卫生.
- 人的肠道微生物组对生活方式的改变很敏感,这引发了关于大流行引起的改变的问题.
研究的目的:
- 调查与流行病相关的生活方式变化对小肠微生物群的影响.
- 为了比较十二指肠微生物组合和相关的细胞因子水平在疫情前和疫情期间.
主要方法:
- 分析了匹配的成人队列 (大流行前与COVID-19阴性大流行内).
- 十二指肠吸附剂经过16S rRNA测序进行微生物组分析.
- 使用Luminex FlexMap3D测量血清中细胞因子水平.
主要成果:
- 在两组之间观察到十二指肠微生物组β多样性的显著差异.
- 极端类动物 (Deinococcus-Thermus, Thermaceae) 在流行内群体中的相对丰度增加.
- 减少了Gram阴性细菌 (Bacteroidetes,Proteobacteria) 和特定属 (Escherichia-Shigella,Rothia) 的相对丰富度,这些细菌在流行内群体中.
- 在流行病内队列中观察到较低的血清中白血素-18水平.
结论:
- 在没有感染的个体中,小肠微生物组的组成在COVID-19大流行期间发生了显著的变化.
- 在代谢上重要的小肠微生物群中的这些变化可能对宿主健康和生理有影响.
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