根据四种统计模型,怀孕早期多种金属与妊娠期糖尿病之间的关联
Luyi Li1, Jialin Xu2, Wenlou Zhang1
1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.
Environmental science and pollution research international
|August 14, 2023
概括
怀孕早期接触金属,包括 (Ni),与妊娠期糖尿病 (GDM) 风险有关. (Ni) 可能降低GDM风险,而其他金属如 (Sr) 和 (Sb) 则显示出积极的关联.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 毒理学 毒理学 毒理学
背景情况:
- 孕期糖尿病 (GDM) 是一种常见的妊娠并发症.
- 对金属的暴露是GDM的新兴风险因素,但金属混合物的影响尚不清楚.
研究的目的:
- 调查早期怀孕金属混合物与GDM风险之间的关联.
- 在混合物中识别影响GDM风险的关键金属.
主要方法:
- 在中国北京的一项嵌套病例对照研究 (128例GDM病例,318例对照).
- 在怀孕13周之前,分析13种金属的尿样.
- 采用单金属分析和三个混合模型:贝叶斯核机器回归 (BKMR),量子g计算和弹性网回归 (ENET).
主要成果:
- 单金属分析表明Ni与较低的GDM风险相关,而Sr和Sb则显示出积极的关联.
- 混合物分析显示,Ni和Mg与GDM负相关,Co和Sb与GDM正相关.
- 在所有混合物模型中, (Ni) 始终被确定为降低GDM风险的关键金属.
结论:
- 怀孕早期的金属暴露与GDM风险有关.
- (Ni) 可能起到保护作用,可能降低GDM风险.
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