在澳大利亚黄金海岸的冠状动脉病例中检测出 gabapentinoid:一项为期5年的回顾性研究
Isabella Thompson1, Zeena Gadsby2, Jeremy Martin2
1Gold Coast University Hospital, Southport, QLD, Australia.
Forensic science, medicine, and pathology
|August 14, 2023
概括
死后毒理学显示,在7.4-12.4%的死亡人群中,普雷加巴林. 普雷加巴林检测显著增加了与药物有关的死亡的可能性,特别是与阿片类药物结合时.
科学领域:
- 法医毒理学 法医毒理学
- 临床药理学 临床药理学
背景情况:
- gabapentinoids 具有镇痛,缓解焦虑和抗作用,处方数量增加和不良结果.
- 局限的区域研究和死后数据阻碍了对 gabapentinoid 使用和相关死亡事故的理解.
- 尸检后的毒理学数据可以描述区域的毒品使用模式,并为干预提供信息.
研究的目的:
- 用死后毒理学数据来描述涉及 gabapentinoids 的与药物相关的死亡.
- 确定在黄金海岸检测前加巴林的模式及其与死亡率的关联.
- 为减轻与 gabapentinoid 相关的危害提供公共卫生策略的信息.
主要方法:
- 黄金海岸大学医院所有死亡病例的5年后期研究,并进行毒理学分析.
- 在已故个体中分析了 gabapentinoid 检测率和人口统计/毒理数据.
- 与药物相关和非药物相关死亡之间的特征与pregabalin检测的比较.
主要成果:
- 普雷加巴林是唯一被检测到的 gabapentinoid,年检测率一致 (7.4-12.4%).
- 普雷加巴林检测与与药物相关死亡的可能性增加了15倍.
- 涉及普雷加巴林的与药物相关的死亡显示药物含量较高,死者年轻,并频繁同时使用阿片类药物.
结论:
- 死后检测到的普雷加巴林是药物相关死亡的重要指标.
- 同时使用普雷加巴林和阿片类药物有助于增加致命药物相关事件的负担.
- 有针对性的公共卫生干预和监管的处方对于解决与普雷加巴林相关的死亡率至关重要.
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