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在帕金森病中,融合和分离的内部和互联网网络连接性与磨损的帕金森病

Heng Zhai^1,2, Wenliang Fan^3,4, Yan Xiao^3,4

¹Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Province, Guangzhou, 510080, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|August 14, 2023

概括

经历磨损的帕金森病患者表现出大脑网络连接的改变. 静止状态网络中的这些功能连接变化有助于区分帕金森病的病理生理学.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

帕金森病 (PD) 是一种神经退行性疾病,影响运动控制.
磨损 (WO) 是PD治疗的常见并发症,表明运动症状波动.
了解WO的神经基础对于改善患者管理至关重要.

研究的目的:

调查具有和没有WO的PD患者的静止状态网络中的功能连接性改变.
为了在PD患者和健康对照者之间比较内部和互联网网络层面的网络完整性.
确定受PD中WO影响的特定大脑区域和网络.

主要方法:

使用了休息状态功能磁共振成像 (fMRI).
包括36名PD患者没有磨损 (PD-nWO),30名PD患者磨损 (PD-WO) 和35名健康对照 (HC).
分析了功能网络的完整性,网络和边缘级别;用于回归分析的临床分数.

主要成果:

与HC相比,PD-WO患者在背部注意力和边缘网络中的连接性减少.
在PD-WO患者中,在12个特定的大脑节点观察到功能连接的程度下降.
与PD-nWO患者相比,PD-WO患者的五对静止状态网络之间也发现了功能连接的减少.

结论:

改变了内部和互联网功能连接的特征是患有WO的PD患者.
这些发现增强了对PD病理生理学中的网络变化的理解.
该研究强调了与帕金森病中磨损现象相关的明显网络变化.

关键词:

功能连接性的功能连接性.互联网工作互联网工作内部网络内部网络内部网络帕金森病是帕金森氏症的一种疾病.磨损的消退 - 磨损的消退

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