评估酒精的实时积极主观影响,使用高分辨率的生态瞬间评估,对风险饮酒者和轻度饮酒者进行实时评估
Daniel J Fridberg1, Zoe Lee1, Andrew M Fischer1
1Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois, USA.
Alcohol, clinical & experimental research
|August 14, 2023
概括
风险饮酒者,包括中度至重度饮酒障碍 (MS-AUD) 患者,在实时体验更多积极的酒精效应. 这项研究使用了高分辨率的生态瞬间评估 (HR-EMA) 来追踪自然环境中的酒精反应.
科学领域:
- 酒精研究研究 酒精研究
- 药物成科学 药物成科学
- 生态瞬间评价 生态瞬间评价
背景情况:
- 高分辨率生态瞬间评估 (HR-EMA) 能够实时评估重度饮酒期间的急性酒精反应.
- 了解不同饮酒群体的主观酒精影响对于有针对性的干预措施至关重要.
研究的目的:
- 使用HR-EMA调查中度至重度饮酒障碍 (MS-AUD),重度社交饮酒者 (HD) 和轻度饮酒者 (LD) 个体的饮酒行为和主观酒精反应.
- 为了比较这些饮酒者小组在自然环境中的急性酒精效应,包括刺激,奖励和镇静.
主要方法:
- 基于智能手机的HR-EMA采用了112名参与者 (54%是男性,平均年龄为27.2岁) 在典型的饮酒场合和非酒精场合中使用.
- 参与者完成了第二天的调查,评估饮酒结果,可接受性和安全性,迅速完成率高 (92%的酒精,89%的非酒精).
主要成果:
- 在MS-AUD组消耗的酒精最多,达到最高估计血中酒精度 (eBAC) 0.14 g/dL,与HD (0.10 g/dL) 和LD (0.02 g/dL) 相比.
- 与LD相比,MS-AUD和HD组都报告了明显更大的积极酒精影响 (刺激,喜欢,想要),即使在控制酒精消费水平时也是如此.
结论:
- 这是第一个利用HR-EMA进行现实世界急性酒精反应测量的研究,涉及多种饮酒者亚组,包括MS-AUD患者.
- 风险饮酒者在重度饮酒期间对酒精的积极影响表现出更高的敏感性,这表明他们比以前理解的更早,更强烈地体验了理想的主观影响.
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