患有Klinefelter综合征的男性的生活质量:一个多中心研究
Sebastian Franik1, Kathrin Fleischer1, Barbara Kortmann2
1Department of Obstetrics and Gynaecology, Radboudumc, Nijmegen, The Netherlands.
Endocrine connections
|August 14, 2023
概括
与健康人相比,患有Klinefelter综合征 (KS) 的男性报告生活质量 (QOL) 显著降低. 歧视和慢性健康问题等因素进一步降低了KS男性的身体,心理和社会福祉.
科学领域:
- 内分泌学和遗传学 在内分泌学和遗传学
- 公共卫生和流行病学
- 心理学与生活质量研究 心理学与生活质量研究
背景情况:
- 克莱因菲尔特综合征 (KS) 与社会经济地位的降低以及患病和死亡风险的增加有关.
- 这些因素可以显著影响受影响个体的整体生活质量 (QOL).
- 了解KS男性的QOL对于有针对性的健康干预至关重要.
研究的目的:
- 调查和量化生活质量 (QOL) 在被诊断患有Klinefelter综合征 (KS) 的大量欧洲男性队列中.
- 为了比较患有KS的男性和健康和精神病参考人群之间的QOL领域.
- 确定与KS男性降低QOL相关的特定因素.
主要方法:
- 一项横截面的多中心研究,涉及218名来自6个欧洲国家的14个临床中心的KS男性.
- 利用世界卫生组织的生活质量 (WHOQOL) -BREF问卷来评估全球,身体,心理,环境和社会QOL领域.
- 结果与健康和精神病参考人群的规范数据进行比较.
主要成果:
- 与健康的参考人群相比,患有KS的男性在QOL的身体,心理和社会领域的得分明显较低.
- 患有KS的男性的QOL得分在身体和心理领域都高于精神病学参考人群的得分.
- 经历过歧视,减少了社交活动,并存在慢性健康问题.
结论:
- 总体而言,与健康男性相比,患有Klinefelter综合征的欧洲男性的整体QOL显著受损.
- 歧视,有限的社会参与和慢性健康问题是减少身体,心理和社会福祉的关键因素.
- 对多学科方法进行进一步的研究是有必要的,以加强心理社会支持,并改善KS男性的质量生活.
相关概念视频
01:20Disorders of the Male Reproductive System
462
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
462
01:23Infertility in Males
295
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
295
02:19The Y Chromosome Determines Maleness
6.7K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.7K
01:43Sex-linked Disorders
102.4K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.4K
01:28Menopause
201
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
201
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K