关于新兴大麻素六大麻素 (HHC) 的研究
Daniel J Nasrallah1, Neil K Garg1
1Department of Chemistry Biochemistry, University of California, Los Angeles, California 90095, United States.
ACS chemical biology
|August 14, 2023
概括
两个六大麻素 (HHC) 异构体 (9R) -HHC和 (9S) -HHC显示出不同的大麻素受体活性. 商业HHC产品具有可变的异构体比率,突出显示需要进一步的研究和安全测试.
科学领域:
- 大麻素科学是关于大麻素的科学.
- 有机化学 有机化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 六大麻素 (HHCs) 是美国越来越多的THC衍生物,通常是异构体混合物.
- 自20世纪40年代以来,人们已经知道HHC,但缺乏全面的科学研究.
- 商业HHC产品显示出异构体比率的显著变化.
研究的目的:
- 合成和描述两个HHC异构体: (9R) -HHC和 (9S) -HHC.
- 评估这些同位素的大麻素受体结合亲和力和活性.
- 评估在商用HHC产品中可变异构体比率的影响.
主要方法:
- 通过原子转移减少合成 (9R) -HHC和 (9S) -HHC.
- 大麻素受体结合测试以确定亲和力.
- 功能性测试用于评估受体活性.
- 对60多种商业HHC产品的分析证书的分析.
主要成果:
- (9R) -HHC被合成为主要的二聚体.
- (9R) -HHC表现出与Δ9-THC相比的结合亲和力和活性.
- (9S) -HHC在功能性试验中表现出强烈的结合,但活性降低.
- 商业HHC产品显示出广泛的异构体比率变化 (0.2:1到2.4:1对于 (9R): (9S)).
结论:
- (9R) -HHC和 (9S) -HHC的不同药理特征是显著的.
- 商业HHC产品的变化需要进一步的研究和标准化测试.
- 这些发现支持明智的大麻政策,提高大麻素安全性和潜在的治疗发现.
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