在肯尼亚西北部的图尔卡纳县出现瘤的第一份报告
María Francisca Colom1,2,3, Consuelo Ferrer1,2, John Lochuke Ekai4
1Laboratory of Medical Mycology, Universidad Miguel Hernández, Avenida Santiago Ramón y Cajal s/n, Edificio Muhammad Al Shafra, Sant Joan d'Alacant, Spain.
PLoS neglected tropical diseases
|August 14, 2023
概括
菌瘤是一种被忽视的热带疾病,影响了肯尼亚的图尔卡纳县. 这项研究确定了Madurella物种是最常见的真菌病因,强调了需要本地诊断和治疗策略的需要.
科学领域:
- 医学真菌学 医学真菌学
- 热带医学 热带医学
- 传染性疾病 传染性疾病
背景情况:
- 瘤是一种被忽视的热带疾病,普遍存在于肯尼亚图尔卡纳县.
- 关于该地区瘤流行率和致病因子的数据有限.
- 这项研究利用当地负担得起的方法解决了诊断差距.
研究的目的:
- 为了估计图尔卡纳县瘤的流行率.
- 为了识别导致菌瘤的主要真菌和细菌病原体.
- 描述研究区域内瘤病例的临床特征.
主要方法:
- 在洛德瓦县推医院 (LCRH) 对疑似瘤患者的前性研究.
- 临床检查,病变取样 (活检) 和数据记录.
- 培养和分子方法 (PCR) 用于从临床样本中识别病原体.
主要成果:
- 研究了60名患者 (74.1%是男性,平均年龄为37岁). 病变主要发生在脚上 (87.9%).
- 确定了21种致病原体 (39.6%的病例);80.9%是真菌.
- 马杜雷拉菌 (M. mycetomatis,M. fahalii) 是最常见的真菌属 (41.2%). 还检测到了Streptomyces somaliensis和新型的动态细菌.
结论:
- 这是自1973年以来肯尼亚的第一个菌瘤报告,也是图尔卡纳县的第一个报告.
- 在该地区,真菌病原体,特别是Madurella物种,是真菌瘤的主要原因.
- 这些发现强调了需要加强对肯尼亚瘤的监测和可访问的诊断工具.
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