肠道有机体的体和体外形态分析分析
Sandra Montes-Olivas1, Danny Legge2, Abbie Lund1
1Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom.
PLoS computational biology
|August 14, 2023
概括
研究人员开发了一种算法来计算肠道有机体中的密室状结构,并改进了一种计算模型来预测它们的生长. 这有助于为临床应用标准化有机体培养.
科学领域:
- 生物技术是生物技术.
- 计算生物学 计算生物学
- 再生医学是一种再生医学.
背景情况:
- 器官体是研究组织生长和治疗的有价值的体外模型.
- 在有机体培养中的变异性阻碍了临床实施,原因是未知的机制和不一致的条件.
- 强大的生物模型和准确的临床研究需要标准化工具.
研究的目的:
- 开发用于评估和预测有机体行为的工具,以提高标准化.
- 为了自动化对肠道有机体中关键形态结构的量化.
- 为了比较体外实验数据与in-silico模型预测.
主要方法:
- 开发了一种算法,用于在肠道器官中自动计算类似密码的结构 (体外和内图像).
- 修改了一个基于2D代理的数学模型来模拟肠道器官生理学.
- 为验证模型,生成了用于体外肠道有机体培养的新实验数据.
主要成果:
- 密码计数算法在第3天和第7天准确地近似了体外培养中的芽结构.
- 修改后的in-silico模型显示了在第5天和第7天在体外数据中观察到的芽结构的复制潜力.
- 这项研究提供了一种方法来量化结构,并比较体外和体内实验结果.
结论:
- 开发的算法和计算模型有助于标准化有机体培养.
- 这些工具可以帮助为临床研究创建更强大的生物模型.
- 未来的扩展可能涉及用于更复杂的模拟的3D in-silico模型.
相关概念视频
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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is covered...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is covered...
Liver Histology
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
Histology of the Large Intestine
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
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External Anatomy of the Kidney
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Internal Anatomy of the Kidney
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...


