针对结直肠癌治疗的向疗法的组合
Elodie Péraudeau1,2, Brigitte Renoux1, Sheik Emambux2,3
1Equipe Labellisée Ligue Contre le Cancer, Université de Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), 4 rue Michel-Brunet, TSA 51106, 86073 Poitiers, Cedex 9, France.
与向性单甲基奥里斯丁E (MMAE) 前药物结合贝瓦西祖马布 (Bev) 显示,与目前的疗法相比,在小鼠的结直肠癌治疗中具有更高的疗效.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 药物运输 药物运输 药物运输
背景情况:
- 开发选择性瘤破坏性疗法是癌症治疗的一个主要挑战.
- 针对性疗法,如贝瓦西祖马布 (Bev) 和细胞毒性有效载荷,如单甲基奥里斯丁E (MMAE) 在现代瘤学中至关重要.
研究的目的:
- 为了评估结合贝瓦齐祖马布 (Bev) 与MMAE (MMAE前药物) 的新型β-葡萄糖酶响应性专蛋白结合前药物用于结直肠癌治疗的疗效.
- 在临床前模型中,将这种新型组合疗法与标准的FOLFOX和Bev疗法进行比较.
主要方法:
- 使用联合Bev和MMAE前药疗法治疗结直肠癌异种移植的小鼠.
- 对治疗活性的评估和与FOLFOX和Bev联合治疗的比较.
- 调查Bev与选择性释放的MMAE之间潜在的协同或添加效应.
主要成果:
- 贝夫和MMAE前药物的组合显示出对小鼠植入结直肠癌的优越治疗活性.
- 这种新的组合表现优于已有的FOLFOX和Bev治疗方案.
- 增强的疗效归因于Bev和MMAE之间的协同作用或添加作用,这些作用在瘤微环境中特别释放.
结论:
- 贝瓦西祖马布与对β-glucuronidase敏感的MMAE前药物相结合,为结直肠癌治疗提供了一个高度有效的策略.
- 这种方法可以显著提高基于MMAE的药物递送系统的治疗指数,包括抗体-药物联体.
- 这些发现表明,使用MMAE有效载荷,对结直肠癌和潜在的其他恶性瘤提供了一个有希望的新治疗途径.
更多相关视频
06:19Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer
Published on: July 18, 2017
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
相关概念视频
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy
Drugs for Treatment of Ulcerative Colitis in IBD
Treatment Resistant Cancers
