在肌缩侧面硬化症/运动神经元疾病中输入管养

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Adrienne Sulistyo^1,2, Agessandro Abrahao³, Maria Eliza Freitas⁴

¹Institute of Medical Science, University of Toronto, Toronto, Canada.

The Cochrane database of systematic reviews

|August 14, 2023

概括

肠道管食,就像皮肤内镜胃口术 (PEG) 一样,常见于肌缩性侧面硬化症 (ALS) 患有食障碍的患者. 然而,没有随机试验证实它对口服养的生存或生活质量的有效性.

科学领域:

神经学神经学
胃肠病学胃肠病学
临床营养学临床营养学

背景情况:

充足的营养对于肌缩性侧面硬化症 (ALS) 或运动神经元疾病 (MND) 患者至关重要.
肠道管食,特别是皮肤内镜胃口术 (PEG),是ALS患者经历食障碍的常见干预措施,以维持营养和预防并发症.
本次审查重点关注PEG在治疗ALS中的作用和有效性.

研究的目的:

评估ALS患者肠管养与口服养在生存,营养状况和生活质量方面的有效性.
评估与皮肤内镜胃口术 (PEG) 和ALS中的其他肠管养程序相关的并发症的发生率.

主要方法:

搜索了多个数据库,包括Cochrane Neuromuscular,CENTRAL,MEDLINE,Embase,ClinicalTrials.gov和WHO ICTRP相关研究.
包括随机对照试验 (RCT),准RCT和交叉试验,评估ALS患者的肠管养有效性和并发症.
采用标准的Cochrane方法程序来收集和分析数据.

主要成果:

没有确定随机对照试验 (RCT) 或准RCT,直接比较ALS患者的肠管养与口服养的有效性.
因此,从RCT中没有经验证据来支持或反驳肠道管养对这一群体的生存,营养状况或生活质量的益处.

结论:

目前来自RCT的证据不足以确定与ALS患者持续口服养相比,肠道管养的有效性.
伦理方面的考虑使得进行这种RCT具有挑战性.
未来的研究可以专注于可行的RCT,检查不同的肠管插入技术和放置的最佳时间,以改善ALS患者的治疗结果.

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