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Updated: Jul 19, 2025

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三阴性乳腺瘤依赖突变p53的生长和生存

Denada Dibra1, Sydney M Moyer1,2, Adel K El-Naggar3

  • 1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.

Proceedings of the National Academy of Sciences of the United States of America
|August 14, 2023
PubMed
概括

在三阴性乳腺癌 (TNBC) 中准突变TP53会减缓瘤的生长. 突变TP53的遗传删除激活了免疫路径并延长了生存期,揭示了对侵略性TNBC瘤的依赖.

关键词:
乳腺癌 乳腺癌 乳腺癌鼠标模型 鼠标模型突变p53的稳定性 突变p53的稳定性瘤细胞的脆弱性 瘤细胞的脆弱性

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