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Updated: Jul 19, 2025

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
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CRISPR/dCas9 DNA甲基化编辑在人类造血过程中是遗传的,并塑造免疫后代

Emily A Saunderson1, Hector Huerga Encabo2, Julie Devis3

  • 1Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|August 14, 2023
PubMed
概括

衰老会增加干细胞中的DNA甲基化 (DNAm). 针对人类干细胞/原始细胞 (HSPC) 中的p15 DNAm改变了小鼠的血细胞发育,显示出血造过程中的表观遗传变化的功能相关性.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?编辑表观遗传学编辑血液形成 血液形成

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