一个随机的临床试验,静脉注射甲基普雷迪尼索隆与2个协议在患有Graves轨道病变的患者
Zhangfang Li1, Yaosheng Luo2,3, Quandi Huang1
1Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
The Journal of clinical endocrinology and metabolism
|August 14, 2023
概括
对于格雷夫斯轨道病 (GO) 的每周和每月静脉注射葡萄糖皮质激素 (IVGC) 治疗显示出类似的疗效和安全性. 每月IVGC协议为GO患者提供了一个可行的替代方案,而不是每周的治疗方案.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 静脉注射葡萄皮质激素 (IVGC) 治疗是对格雷夫斯轨道病 (GO) 的公认治疗方法.
- 虽然4.5克IVGC协议已经确立,但最佳的剂量计划需要进一步调查.
- 澄清治疗方案可以提高GO管理中的患者结果.
研究的目的:
- 为了比较每周和每月IVGC协议在Graves轨道病患者的疗效和安全性.
- 评估不同IVGC施用频率对GO治疗结果的影响.
- 为了确定月度IVGC计划是否是一种安全有效的替代每周给药方案.
主要方法:
- 一个前性的,随机的,观察者蒙面的,单中心的临床试验.
- 58名患有活跃,中度至重度GO的患者接受了每周或每月一次IVGC协议 (共12周内4.5克甲基prednisolone).
- 测量结果包括整体有效率,生活质量 (QOL),信号强度比 (SIR),临床活性评分,外眼,软组织参与和双眼视,直到第24周.
主要成果:
- 在12周和24周,每周和每月IVGC组之间没有观察到有效率的显著差异.
- 在QOL的改善,临床活动得分,外眼,软组织参与和双眼视在两组之间是可比的.
- 在每周和每月IVGC协议之间,不良事件发生率和SIR变化没有显著差异.
结论:
- 对于Graves轨道病的每周和每月IVGC协议显示了可比的疗效和安全性.
- 每月IVGC的服用时间表可以被认为是治疗GO的每周方案的合适替代方案.
- 这些发现支持灵活的IVGC剂量策略,用于管理Graves轨道病变.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
153
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
153
Adrenal Gland Disorders
1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
195
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
195
Open Angle Glaucoma: Treatment
479
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
479
Clinical Trials: Overview
3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Clinical Trials
6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.9K


