粗粒的超结构在周围的空间和与排卵诱导协议的关联
Sibel Bulgurcuoglu-Kuran1, Ayse Altun1, Fatma Nur Karakus2
1IVF Unit, Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkiye.
JBRA assisted reproduction
|August 14, 2023
概括
卵细胞周体空间 (PVS) 中的粗颗粒与胚胎发育不良和流产率增加有关. 积极的排卵诱导协议可能会对辅助生殖中的卵细胞质量产生负面影响.
科学领域:
- 生殖生物学 生殖生物学
- 卵细胞的超结构
- 辅助生殖技术 辅助生殖技术
背景情况:
- 周周细胞空间 (PVS) 在受精和早期胚胎发育中起着至关重要的作用.
- 卵细胞质量是成功辅助生殖结果的关键决定因素.
- 在PVS中观察到颗粒,但其起源和影响尚未完全理解.
研究的目的:
- 为了研究人类卵细胞PVS中的粗粒的起源和超结构.
- 评估这些颗粒和排卵诱导协议之间的相关性.
- 评估PVS颗粒对卵细胞和胚胎发育能力的影响.
主要方法:
- 使用传输电子显微镜 (TEM) 用PVS颗粒检查卵细胞的超结构.
- 对214对接受辅助生殖治疗的夫妇进行了回顾性分析.
- 颗粒存在,排卵诱导参数和胚胎质量之间的相关性分析.
主要成果:
- 经过TEM检测,PVS中的不规则的微和脂质滴以及具有颗粒的卵子细胞的累积细胞.
- 颗粒的存在与对抗剂的服用时间正相关.
- PVS颗粒与低质量的胚胎,更高的胚胎停止率和更高的流产有关.
结论:
- PVS中的粗颗粒与胚胎发育能力的降低有关.
- 这些发现表明,积极的排卵诱导协议对卵细胞质量有负面影响.
- PVS颗粒可以作为卵细胞质量和潜在生殖结果的标志物.
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