硫酸性利尿剂和结肠直肠癌风险:基于人口的队列研究
American journal of epidemiology
|August 14, 2023
概括
与二皮里丁路阻断剂相比,酸性利尿剂不会增加整体结直肠癌的风险. 然而,在患有炎症性肠道疾病或多的患者中,发现风险增加.
科学领域:
- 药物监督 药物监督 药物监督
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 关于 thiazide 利尿剂和结直肠癌风险,存在相互矛盾的证据.
- 二皮里丁通道阻断剂 (dCCB) 作为一种比较药物类.
研究的目的:
- 调查 thiazide 利尿剂与结直肠癌风险之间的关联.
- 为了比较 thiazide 利尿剂启动剂与 dCCB 启动剂.
主要方法:
- 基于人口的新用户队列研究,使用英国临床实践研究数据链接 (1990-2018).
- 考克斯的比例危险模型具有标准化的发病率权重和倾向性得分调整.
- 在 thiazide 利尿剂和 dCCB 启动剂之间比较结直肠癌发病率.
主要成果:
- thiazide利尿剂与整体结直肠癌风险之间没有显著的关联 (加权HR=0.97,95%CI:0.90,1.04).
- 在患有炎症性肠道疾病的患者中观察到结直肠癌风险升高 (加权HR=2.45,95%CI:1.13,5.35).
- 患者有史以来的息肉 (加权HR=1.46,95%CI:0.93,2.30) 的潜在风险增加.
结论:
- 与dCCB相比, thiazide利尿剂与整体结直肠癌风险增加无关.
- 需要进一步的研究来确认特定患者亚组的风险增加,包括患有炎症性肠病和多重体的患者.
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