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蜂可以通过减轻炎症和氧化损伤来预防血管内皮功能障碍,在老鼠的慢性不可预测的压力模型中,这种模式是抑郁症

Gulsen Celebi¹, Semil Selcen Gocmez¹, Cuneyt Ozer²

¹Faculty of Medicine, Department of Pharmacology, Kocaeli University, Kocaeli, Turkey.

The Journal of pharmacy and pharmacology

|August 14, 2023

概括

蜂在慢性压力小鼠模型中表现出抗抑郁和血管保护作用. 这种天然化合物可以通过抗炎和抗氧化作用防止压力诱导的血管内皮功能障碍.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
心血管科学心血管科学

背景情况:

慢性压力与抑郁症和血管内皮功能障碍有关.
慢性不可预测的轻度压力 (CUMS) 模型在老鼠中被用来研究抑郁症.
血管内皮功能障碍涉及氧化合成酶 (eNOS),炎症性细胞因子 (TNFα,IL-1β) 和抗氧化酶 (HO-1,SOD) 的失衡.

研究的目的:

在CUMS诱导的抑郁症的小鼠模型中研究石对血管功能的影响.
探索的血管效应背后的潜在机制.

主要方法:

雄性Wistar大鼠在5周内接受了CUMS模型.
提取物 (100毫克/公斤/天) 被口服给治疗组.
使用强迫游泳测试 (FST) 评估了类似抑郁症的行为.
评估了血管内皮功能,皮质水平和蛋白质表达 (eNOS,TNFα,IL-1β,HO-1,SOD).

主要成果:

CUMS诱导了类似抑郁症的行为,皮质水平升高,以及血管内皮功能受损.
压力显著降低了eNOS,SOD和HO-1表达,同时增加了TNFα和IL-1β.
administration 改善了类似抑郁症的行为,改善了血管内皮功能,并使蛋白质表达正常化.

结论:

在CUMS诱导的抑郁症模型中, прополис表现出类似抗抑郁药和血管保护作用.
慢性 прополис治疗可以通过抗炎和抗氧化途径防止CUMS诱导的血管内皮功能障碍.

关键词:

抗氧化剂是一种抗氧化剂.慢性压力是一种慢性压力.抑郁抑郁症抑郁症抑郁症是一种这是一种炎症炎症炎症炎症.普罗波利斯 (propolis) 是一种植物.血管功能血管功能

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