肝酶调解了阿尔代合暴露和高甘油三血症之间的关联
Duanbin Li1, Zhezhe Chen1, Yu Shan1
1Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, People's Republic of China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou 310000, Zhejiang, People's Republic of China.
暴露于化物与高甘油三血症 (HTG) 有关. 某些甲基化物及其联合暴露显示出与HTG的积极关联,可能由ALT,AST和GGT等肝酶介导.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 化物是已知影响脂质代谢的环境毒性物质.
- 氨酸会增加血清甘油三酸 (TG) 水平,但其他化物对高甘油三酸 (HTG) 的影响和潜在机制尚不清楚.
研究的目的:
- 为了研究血清化物,肝酶和HTG之间的关联.
- 探索肝酶在化物和HTG之间的关系中的潜在调解作用.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2013-2014) 的横截面研究.
- 分析了各种甲基化物 (例如,4碳甲基化物,5碳甲基化物) 和肝酶 (ALT,AST,ALP,GT) 的血清水平.
- 采用加权量子素和 (WQS) 回归,贝叶斯核机回归 (BKMR) 和调解分析.
主要成果:
- 甲基 (4AL),甲基 (5AL),异甲基 (I5AL) 和甲基 (7AL) 与HTG正相关.
- 联合阿尔德海德暴露与HTG (OR 1.706) 有积极的关联,5AL是主要的贡献者.
- 合暴露与ALT,AST和GT的升高相关;这些肝酶也与HTG有关.
- 肝酶 (ALT,AST,GGT) 部分调解了5AL,7AL和HTG之间的关联.
结论:
- 合暴露与过高甘油三血症有积极关联.
- 肝酶在特定的化物和HTG之间的联系中起着部分调解作用.
- 研究结果强调化物是导致脂质不良的潜在因素,并表明向肝酶通路.
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