住院患者的COVID-19死亡率:一个新的系统性审查和元分析
Alexandre Baptista1, Ana M Vieira1, Eunice Capela1
1Faculdade de Medicina e Ciências Biomédicas Universidade Algarve, Faro, Portugal.
Journal of infection and public health
|August 14, 2023
概括
全球COVID-19患者的医院死亡率为16%. 这一更新的元分析提供了有关传染病结果和流行病影响的关键见解.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致了COVID-19大流行,在2019年底出现.
- 之前的元分析确定了基线医院死亡率.
- 这项研究更新了考虑到新疗法和疫苗接种努力的数据.
研究的目的:
- 更新全球COVID-19患者的医院死亡率.
- 分析住院患者的临床特征和结果.
- 在不断变化的流行病管理策略中提供当前数据.
主要方法:
- 在PubMed和EMBASE数据库的系统文献搜索.
- 使用随机效应模型 (曼特尔-汉泽尔方法) 的元分析.
- 使用Tau2和Chi2统计数据对异质性的统计分析.
主要成果:
- 分析包括来自46项研究的114,609名患者.
- 对于COVID-19患者的整体医院死亡率为16% (95%CI12%;21%).
- 显著的异质性 (I2 = 100%) 表明了跨研究的变化.
结论:
- 全球COVID-19一般患者的医院死亡率为16%.
- 死亡率在不同地理区域有很大差异.
- 调查结果强调需要持续监测和区域化的公共卫生干预措施.
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