在骨中的高级糖化和糖氧化最终产品
Bowen Wang1, Deepak Vashishth2
1Shirley Ann Jackson Ph.D. Center of Biotechnology and Interdisciplinary Studies, Troy, NY 12180, USA; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Bone
|August 14, 2023
概括
先进的糖化和氧化终产物 (AGEs/AGOEs) 在骨中积累,在糖尿病和衰老中恶化骨脆弱性. 针对这些产品可能有助于预测和管理骨折.
科学领域:
- 生物化学 生物化学
- 整形外科 整形外科 整形外科
- 老年学是一门学科.
背景情况:
- 高血糖和氧化应激加快了骨中先进的糖化和糖氧化最终产品 (AGEs/AGOEs) 的积累.
- AGEs/AGOEs被认为是与糖尿病,衰老和骨质疏松症相关的骨脆弱性的关键因素,不仅仅是骨质和跌倒.
- 这些最终产品通过改变有机基质,矿物质和水含量来对骨质质量产生负面影响,扰乱骨的循环.
研究的目的:
- 审查AGEs/AGOEs在骨中的积累机制.
- 阐明AGE/AGOE对骨质和骨折风险的影响.
- 讨论目前针对骨折管理的AGE/AGOE的临床前和临床策略.
主要方法:
- 对骨中AGE/AGOE研究的文献综述.
- 对AGEs/AGOEs对骨组织的生物化学和生物力学影响的分析.
- 检查针对AGE/AGOE的治疗策略.
主要成果:
- 由于高血糖和氧化应激,AGE/AGOE会在骨中积累.
- 骨质因AGE/AGOE而恶化,导致骨折风险增加.
- AGEs/AGOEs与除了糖尿病和衰老之外的疾病,包括阿尔茨海默病,昼夜干扰和癌症的骨脆弱性有关.
结论:
- AGEs/AGOEs是骨脆弱的一个关键决定因素,特别是在老龄化和糖尿病患者中.
- 准AGE/AGOE为骨折提供了新的治疗和诊断方法的潜力.
- 需要进一步的研究,以充分理解和利用骨健康中的AGE/AGOE途径.
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