来自维吾尔族药物Salvia deserta的克莱罗丹二类药物具有免疫抑制活性
Xue Ren1, Xin Yuan1, Shan-Shan Jiao1
1State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Phytochemistry
|August 14, 2023
概括
来自Salvia deserta的六种新的克莱罗丹二类药物显示出免疫抑制活性. 一种化合物显著抑制了巨细胞中的瘤亡因子-α (TNF-α) 和互白素-6 (IL-6) 分泌.
科学领域:
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 萨尔维亚物种是生物活性化合物的丰富来源.
- 维吾尔族传统医药使用沙尔维亚种来治疗各种疾病.
- 迪特尔类是一种具有多样化的生物活动的自然产品类.
研究的目的:
- 从Salvia deserta.中分离和描述新型的克莱罗丹二甲类物质.
- 评估分离化合物的免疫抑制潜力.
- 为了确定免疫抑制活性的特定分子点.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过广泛的光谱分析 (NMR,HRESIMS,IR) 阐明结构.
- 使用计算的ECD和X射线衍射来确定绝对配置.
- 在体外检测免疫抑制活性,使用RAW264.7巨细胞测量细胞因子分泌 (TNF-α,IL-6).
主要成果:
- 从Salvia deserta.中分离出6种新的和5种已知的克莱罗丹二甲.
- 所有分离的化合物都具有终端α,β-不和-γ-乳部分.
- (5R,8R,9S,10R)-18-nor-cleroda-2,13-dien-16,15-olide-4-one显示显著抑制TNF-α和IL-6的分泌.
- 这种化合物对TNF-α和IL-6抑制的IC50值分别为8.55微米和13.65微米.
结论:
- 沙漠是一种有价值的结构多样化的clerodane diterpenoids的来源.
- 这些已识别的化合物具有显著的免疫抑制特性.
- 特定的二甲 (5R,8R,9S,10R)-18-nor-cleroda-2,13-dien-16,15-olide-4-one显示出作为一种免疫抑制剂的潜力.
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