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埃米林2通过促进细胞周围细胞招募来促进血管稳定性

Albina Fejza¹, Lucrezia Camicia², Greta Carobolante²

¹Department of Research and Diagnosis, Division of Molecular Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy; UBT-Higher Education Institution, Kalabria, Street Rexhep Krasniqi Nr. 56, Prishtina 10000, Kosovo.

Matrix biology : journal of the International Society for Matrix Biology

|August 14, 2023

概括

拉斯微纤维细胞接口2 (Emilin2) 对细胞周围细胞功能至关重要,增强血管稳定性和在瘤中药物输送. 埃米林2促进细胞周围细胞的招募,并可能作为癌症生物标志物.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
在瘤学瘤学.

背景情况:

血管新生对于正常和病理过程至关重要,包括癌症.
内皮细胞和细胞周细胞功能是由细胞因子,生长因子和细胞外基质组件调节的.
在Emilin2淘汰赛小鼠中的瘤血管显示细胞周周覆盖率降低和药物输送受损.

研究的目的:

研究Elastin微纤维细胞接口2 (Emilin2) 在细胞周周生理学和血管稳定中的作用.
确定Emilin2对周细胞招募和瘤血管功能的影响.
探索Emilin2作为癌症预后的潜在生物标志物.

主要方法:

利用Emilin2淘汰赛小鼠模型研究瘤血管结构.
通过用重组埃米林治疗的内皮细胞评估细胞因子合成 (PDGF-BB,HB-EGF).
研究了Emilin2与细胞整合素 (α5β1,α6β1) 的相互作用,以及它通过氨酸-1-酸盐受体信号传递对N-cadherin表达的影响.
评估了恢复细胞覆盖面对瘤药物输送的影响.

主要成果:

埃米林2缺乏导致皮质细胞覆盖率下降,血管输液受损,并在瘤中降低药物的疗效.
埃米林2刺激内皮细胞产生更多的PDGF-BB和HB-EGF,促进细胞周围细胞的招募.
埃米林2通过引入α5β1和α6β1整合素,充当皮细胞的粘附基质和触角刺激剂.
埃米林2增加了N-cadherin的表达,通过内皮细胞-细胞连接增强了血管稳定性.
在埃米林2缺陷瘤中恢复细胞周周覆盖改善了药物输送.

结论:

埃米林2是细胞周细胞功能的关键调节剂,对血管成熟和稳定至关重要.
埃米林2通过细胞因子的产生和直接的细胞矩阵相互作用影响细胞周围细胞的招募.
埃米林2增强了血管完整性,并通过促进细胞周围覆盖来改善瘤药物输送.
埃米林2表达可能作为黑色素瘤,卵巢和其他癌症的临床结果的预测生物标志物.

关键词:

细胞外矩阵是细胞外矩阵.瘤微环境是一个微环境.血管稳定性血管稳定性

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