使用患者报告的结果措施评估静脉血栓塞栓症的老年患者的生活质量
Justine Deschamps1, Damien Choffat1, Andreas Limacher2
1Division of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Cozerland.
Journal of thrombosis and haemostasis : JTH
|August 14, 2023
概括
静脉血栓塞栓症 (VTE) 的老年患者的生活质量 (QoL) 通常会随着时间的推移而改善. 然而,VTE并发症显著降低了以后的QoL结果.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 健康 结果 研究 研究 结果
背景情况:
- 患有静脉血栓塞栓症 (VTE) 的老年患者 (≥65岁) 面临着重大的健康挑战.
- 评估生活质量 (QoL) 对于了解VTE在这个人口群体中的长期影响至关重要.
- 像复发,出血和血栓后综合征这样的VTE并发症可能会对患者的福祉产生负面影响.
研究的目的:
- 评估诊断为静脉血栓塞栓症 (VTE) 的老年患者的生活质量 (QoL).
- 研究VTE并发症对老年人长期生活质量的影响.
- 在24个月的时间内分析通用和疾病特异性QoL指标的变化.
主要方法:
- 对923名患有急性症状性静脉瘤的老年患者进行了前性多中心队列研究 (SWITCO65+).
- 使用患者报告的结果指标 (PROMs),包括SF-36 (PCS,MCS) 和疾病特定仪器 (VEINES-QoL,VEINES-Sym,PE QoL).
- 采用纵向潜伏类分析和重复测量线性回归来分析QoL轨迹和并发症效应.
主要成果:
- 通过通用和疾病特异性PROMs评估的QoL得分,在24个月内显示出改善 (例如,PCS +11%,VEINES QoL +6%).
- 包括复发 (11%) 和严重出血 (12%) 在内的VTE并发症与显著较低的QoL得分有关.
- 身体成分得分 (PCS) 轨迹较低的患者更可能是老年,女性,病情较差,活动较少.
结论:
- 虽然QoL通常会改善VTE后,但并发症会大大降低患者的福祉.
- 有效管理VTE并发症对于优化老年患者的长期QoL至关重要.
- 该研究强调了PROMs在评估VTE患者结果中的重要性.
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