对于急性单极或双极抑郁症发作患者的双边达爆发刺激:随机对照研究的系统综述
Zhen-Juan Qin1, Shan-Qing Huang2, Xian-Jun Lan1
1The Brain Hospital of Guangxi Zhuang Autonomous Region, LiuZhou, China.
Journal of affective disorders
|August 14, 2023
概括
双边甲爆刺激 (TBS) 显著改善情绪障碍症状,特别是在严重抑郁症 (MDD) 患者中. 这种重复性横磁刺激 (rTMS) 是安全有效的,具有与假装治疗类似的副作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 情绪障碍对全球健康构成重大负担.
- 重复性横磁刺激 (rTMS) 为治疗耐药抑郁症提供了一种非侵入性神经调节方法.
- 甲爆刺激 (TBS) 是一种特定的rTMS协议,效率因参数和目标而异.
研究的目的:
- 评估双边甲爆刺激 (TBS) 对情绪障碍的疗效和安全性.
- 为了在随机对照试验 (RCT) 中比较活跃双边TBS与假刺激.
- 评估患有主要抑郁症 (MDD) 和双相情感障碍 (BD) 的患者的抗抑郁药反应和缓解率.
主要方法:
- 对RCT进行系统搜索,截至2022年12月7日.
- 随机效应对研究定义的反应和缓解率的元分析.
- 包括6个RCT,共285名参与者 (MDD和BD).
主要成果:
- 在MDD患者中,双边TBS在实现响应 (55.1%对20.3%) 和缓解 (37.2%对14.3%) 方面显著优于假刺激.
- 在MDD和混合抑郁症的8周随访中观察到持续的抗抑郁作用.
- 停药率和不良事件 (头痛,头) 在活跃的TBS和假药组之间是可比的.
结论:
- 针对背侧前额皮质 (DLPFC) 的双边TBS是一种耐受性良好且有效的MDD治疗方法.
- 需要进一步研究双边TBS在双极和单极混合抑郁症的疗效.
- 双边TBS代表了一种有希望的神经调节策略,用于管理情绪障碍.
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