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Updated: Jul 19, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Published on: January 9, 2020

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通过孟德尔的随机化和全基因组的同地化,推断大脑成像衍生的表型与复杂疾病风险之间的遗传关系

Siying Lin1, Haoyang Zhang2, Mengling Qi3

  • 1Department of Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; School of Computer Science and Engineering, Sun Yat-Sen University, Guangzhou 510006, China.

NeuroImage
|August 14, 2023
PubMed
概括

大脑成像表型 (IDP) 显示与大脑和心血管疾病有共同的遗传. 门德尔的随机化揭示了IDP可能因果关系地影响重大抑郁症,自闭症,精神分裂症和ALS的风险.

关键词:
脑部疾病 脑部疾病脑成像衍生出来的表型心血管疾病的心血管疾病.原因关系是因果关系.遗传相关性 遗传相关性

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